2007

Developmental Biology

Activity-dependant neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for emryogenesis.

Pharmacology & Therapeutics

Activity-dependent neuroprotective protein: from gene to drug candidate

Current Pharmaceutical Design

NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis.

Journal of Molecular Neuroscience

Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage

Expert Opinon on Therapeutic Targets

The role of vasoactive intestinal peptide in neuroprotection: Professor Illana Gozes is interviewed by Emma Quigley.

Expert Opinion on Investigational Drugs

Looking for novel ways to treat the hallmarks of Alzheimer's disease.

The Journal of Pharmacology and Experimental Therapeutics

Activity-dependent neuroprotective protein snippet NAP reduces tau hyperphosphorylation and enhances learning in a novel transgenic mouse model

Journal of Molecular Neuroscience

Blockage of VIP during mouse embryogenesis modifies adult behavior and results in permanent changes in brain chemistry

Peptides

NAP protects hippocampal neurons against multiple toxins

Journal of Biological Chemistry

Activity-dependent neuroprotective protein constitutes a novel element in the SWI/SNF chromatin remodeling complex.

Journal of Molecular Neuroscience

Vasoactive intestinal peptide (VIP) regulates activity-dependent neuroprotective protein (ADNP) expression in vivo

Journal of Neurochemistry

Silencing of the ADNP-family member, ADNP2, results in changes in cellular viability under oxidative stress

Current Pharmaceutical Design

Vasoactive intestinal peptide receptors: a molecular target in breast and lung cancer

Peptides

Novel analogs of VIP with multiple C-terminal domains

Journal of Peptide Science

Novel glycosylated VIP analogs: synthesis, biological activity, and metabolic stability

2006

Journal of Neurochemistry

NAP mechanism of action is based on a selective interaction with brain-specific tubulin.

Current Alzheimer Research

The neuropeptide, vasoactive intestinal peptide, functions as a neuroprotective agent that acts through glial cells to increase and modulate the synthesis and secretion of novel neuroprotective substances.

Journal of Pharmacology and Experimental Therapeutics

NAP shows efficacy in a model of perinatal hypoxic injury which demonstrates its potential in treating hypoxic ischemic encephalopathy and other indications involving ischemia, such as stroke.

Journal of Molecular Neuroscience

Tubulin is the target binding site for NAP-releated peptides.

Brain Research. Brain Research Reviews

Brain deficits associated with fetal alchol exposure may be protected, in part, by peptides derived from activity-dependent neurotrophic factor and activity-dependent neuroprotective protein.

Molecular & Cellular Endocrinology

Recombinant activity-dependent neuroprotecitve protein protects cells against oxidative stress.

2005

Current Pharmaceutical Design
NAP and ADNF-9 protect normal and Down syndrome cortical neurons from oxidative damage and apoptosis.

Journal of Neuroscience
PolyADP-Ribosylation Is Involved in Neurotrophic Activity.

Peptides

The influence of the peptide NAP on mac-1 deficient mice following closed head injury.

Current Alzheimer Research
The expression of activity-dependent neuroprotective protein (ADNP) is regulated by brain damage and treatment of mice with the ADNP derived peptide, NAP, reduces the severity of traumatic head injury.

Investigative Ophthalmology & Visual Science
The peptides ADNF-9 and NAP increases survival and neurite outgrowth of rat retinal ganglion cells in vitro.

Journal of Molecular Neuroscience
Activity dependent neurotriphic factor-9 (ADNF-9) and NAP promote neurite outgrowth in rat hippocampal and cortical cultures.

Neuroscience Letter
Sexual dimorphism of activity-dependent neuroprotective protein in the mouse arcuate nucleus.

2004

Neuron Glia Biology
Subcellular localization and secretion of activity-dependent neuroprotective protein in astrocytes.

Journal of Pharmacology and Experimental Therapeutics
Ethanol antagonist peptides: Structural specificity without stereospecificity.

Journal of Pharmacology and Experimental Therapeutics
Protective peptides that are orally active and mechanistically nonchiral.

Journal of Biological Chemistry
A femtomolar acting octapeptide interacts with tubulin and protects astrocytes against zinc intoxication.

Neuroscience Letter
Intranasal administration of NAP, a neuroprotective peptide, decreases anxiety-like behavior in aging mice in the elevated plus maze.

Journal of Molecular Neuroscience
Apolipoprotein E knockout mice as a model of behavioral dysfunction.

Journal of Molecular Neuroscience
Nap mechanisms of neuroprotection.

Journal of Molecular Neuroscience
Brain injury-dependent expression of activity-dependent neuroprotective protein.

Regulatory Peptides
Differential regulation of activity-dependent neuroprotective protein in rat astrocytes by VIP and PACAP.

Best Practice and Research Clinical Endocrinology and Metabolism
Potential clinical applications of vasoactive intestinal peptide: A selected update.

Journal of Molecular Neuroscience
Parkinson's and Alzheimer’s diseases: Protein aggregations and neuroprotection.

Journal of Alzheimer's Disease
The femtomolar-acting NAP interacts with microtubules: Novel aspects of astrocyte protection.

2003

Regulatory Peptides
VIP and PACAP regulate activity-dependent neuroprotective protein (ADNP), a gene that shapes and protects the brain.

Program No 9521 Abstract Viewer/ Itinerary Planner Washington, DC: Society for Neuroscience.
Treatment of experimental encephalomyelitis by intranasal application of ADNP peptide, NAP.

Current Pharmaceutical Design
VIP and drug design.

Neuroreport
Injections of the neuroprotective peptide NAP to newborn mice attenuate head-injury-related dysfunction in adults.

Neuropeptides
Complex array of cytokines released by vasoactive intestinal peptide.

Proceedings of the National Academy of Sciences USA
Differential effects of ethanol antagonism and neuroprotection in peptide fragment NAPVSIPQ prevention of ethanol-induced developmental toxicity.

Neuropeptides
Summer neuropeptide conference. The 3rd joint meeting of the summer Neuropeptide Conference (13th annual meeting) and the European Neuropeptide Club (13th annual meeting).

Developemental Brain Research
Activity-dependent neuroprotective protein: A novel gene essential for brain formation.

Journal of Molecular Neuroscience
From vasoactive intestinal peptide (VIP) through activity-dependent neuroprotective protein (ADNP) to NAP: A view of neuroprotection and cell division

American Journal of Obstetrics & Gynecology
The role of activity-dependent neuroprotective protein in a mouse model of fetal alcohol syndrome.

Peptides
The neuroprotective peptide NAP inhibits the aggregation of the beta-amyloid peptide.

2002

Journal of Molecular Neuroscience
A single administration of the peptide NAP induces long-term protective changes against the consequences of head injury: Gene atlas array analysis.

Stroke
NAP, a femtomolar-acting peptide, protects the brain against ischemic injury by reducing apoptotic death.

Journal of Molecular Neuroscience
Protein synthesis in nuclei: When did the story start?

Journal of Molecular Neuroscience
NAP accelerates the performance of normal rats in the water maze.

Regulatory Peptides

Vasoactive intestinal peptide mRNA and immunoreactivity are decreased in fetal alcohol syndrome model.

Journal of Pharmacology and Experimental Therapeutics
Peptide antagonists of ethanol inhibition of l1-mediated cell-cell adhesion.

Life Science
A vasoactive intestinal peptide receptor analog alters the expression of homeobox genes. Differential expression of embryonic and maternal activity dependent neuroprotective protein during mouse development.

Regulatory Peptides
In vitro and in vivo treatment of colon cancer by VIP antagonists.

American Journal of Obstetrics and Gynecology

Differential expression of embryonic and maternal activity-dependent neuroprotective protein during mouse development.

Journal of Molecular Neuroscience
Tau as a drug target in Alzheimer’s disease.

2001

Journal of Biological Chemistry
Cloning and characterization of the human activity-dependent neuroprotective protein.

Journal of Pharmacology and Experimental Therapeutics
A peptide derived from activity-dependent neuroprotective protein (ADNP) ameliorates injury response in closed head injury in mice.

Journal of Pharmacology and Experimental Therapeutics
Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome.

Neuroscience Letter
Vasoactive intestinal peptide and related molecules induce nitrite accumulation in the extracellular milieu of rat cerebral cortical cultures.

Trends Neuroscience
Neuropeptides: Brain messengers of many faces.

Trends Neuroscience
Neuroprotective peptide drug delivery and development: Potential new therapeutics.

Journal of Molecular Neuroscience
Alzheimer's disease: My point of view.

2000

Brain Research
Vasoactive intestinal peptide (VIP) prevents neurotoxicity in neuronal cultures: Relevance to neuroprotection in parkinson's disease.

Journal of Molecular Neuroscience
A new concept in the pharmacology of neuroprotection.

Journal of Pharmacology and Experimental Therapeutics
Activity-dependent neurotrophic factor: Intranasal administration of femtomolar-acting peptides improve performance in a water maze.

Biochemical Society Transactions
Protective peptides derived from novel glial proteins.

Journal of Neuroscience
A glial-derived signal regulating neuronal differentiation.

Regulatory Peptides
A novel peptide prevents death in enriched neuronal cultures.

Annals of the New York Academy of Sciences
A novel VIP responsive gene. Activity dependent neuroprotective protein.

Journal of Molecular Neuroscience
VIP and peptides related to activity-dependent neurotrophic factor protect pc12 cells against oxidative stress.

Journal of Molecular Neuroscience
VIP-related protection against lodoacetate toxicity in pheochromocytoma (pc12) cells: A model for ischemic/hypoxic injury.

1999

Proceedings of the National Academy of Sciences USA
Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation.

Neuroscience Letter
A femtomolar-acting neuroprotective peptide induces increased levels of heat shock protein 60 in rat cortical neurons: A potential neuroprotective mechanism.

Peptides
SNV, a lipophilic superactive VIP analog, acts through cGMP to promote neuronal survival.

Current Medicinal Chemistry
Pharmaceutical VIP: Prospects and problems.

Annals of the New York Academy of Sciences
Vasoactive intestinal peptide. Link between electrical activity and glia-mediated neurotrophism.

Annals of the New York Academy of Sciences
A novel signaling molecule for neuropeptide action: Activity-dependent neuroprotective protein.

Journal of Neurochemistry
Activity-dependent neurotrophic factor peptide (ADNF-9) protects neurons against oxidative stress-induced death.

Annals of the New York Academy of Sciences
Vasoactive intestinal peptide regulates embryonic growth through the action of activity-dependent neurotrophic factor.