Research Publications

Allon is proud to collaborate with leading scientists around the globe to advance the study of neurodegenerative disease and potential new treatment options. Following is a catalog of selected research highlights.

Pre-Clinical Data

Gozes I. Microtubules, schizophrenia and cognitive behavior: Preclinical development of davunetide (NAP) as a peptide-drug candidate. Peptides. 2010 Nov 2. [Epub ahead of print] PubMed PMID: 21050875.

Gozes I. Tau Pathology and Future Therapeutics. Curr Alzheimer Res. 2010 Aug 2. [Epub ahead of print] PubMed PMID: 20678069.

Merenlender-Wagner A, Pikman R, Giladi E, Andrieux A, Gozes I. NAP (davunetide) enhances cognitive behavior in the STOP heterozygous mouse–a microtubule-deficient model of schizophrenia. Peptides. 2010 Jul;31(7):1368-73. Epub 2010 Apr 22. PubMed PMID: 20417241.

Gozes I, Stewart A, Morimoto B, Fox A, Sutherland K, Schmechel D. Addressing Alzheimer’s disease tangles: from NAP to AL-108. Curr Alzheimer Res. 2009 Oct; 6(5):455-60. Review. PubMed PMID: 19874271.

Zemlyak I, Manley N, Vulih-Shultzman I, Cutler AB, Graber K, Sapolsky RM, Gozes I. The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy. J Neurochem. 2009 Dec;111(5):1252-63. Epub 2009 Oct 3. PubMed PMID: 19799711.
Zemlyak I, Sapolsky R, Gozes I. NAP protects against cytochrome c release: inhibition of the initiation of apoptosis. Eur J Pharmacol. 2009 Sep 15;618(1-3):9-14. Epub 2009 Jul 18. PubMed PMID: 19619522.

Shiryaev N, Jouroukhin Y, Giladi E, Polyzoidou E, Grigoriadis NC, Rosenmann H, Gozes I. NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model. Neurobiol Dis. 2009 May;34(2):381-8. Epub 2009 Mar 2. PubMed PMID: 19264130.

Paviour DC, Price SL, Jahanshahi M, Lees AJ, Fox NC. Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophy. Brain. 2006 Apr;129(Pt 4):1040-9. Epub 2006 Feb 2. PubMed PMID: 16455792.

Burn DJ, Lees AJ. Progressive supranuclear palsy. Handb Clin Neurol. 2007;84:327-49. PubMed PMID: 18808956.

Bak TH. Movement disorders: why movement and cognition belong together. Nat Rev Neurol. 2011 Jan;7(1):10-2. Epub 2010 Dec 7. PubMed PMID: 21135883.

Please note that the links above go to the PubMed website. PubMed is a service of the National Library of Medicine that includes more than 16 million citations from MEDLINE and other life science journals for biomedical articles back to the 1950′s. PubMed includes links to full text articles and other related resources. These links will open in a new browser window. Please read NCBI’s disclaimer and copyright notice.